I’m a Pathologist: The "Biological Cost" of Ozempic and Mounjaro.

Miracles don’t exist in biology, mechanisms do. GLP1 medications (Ozempic, Wegovy, Mounjaro, Zepbound) are no exception. And every time you override a biological system that took two million years to evolve, you are making a trade. Every trade has an invoice.
I’m Dr. Amin Hedayat, a triple board-certified physician and clinical assistant professor of medicine. In this video, we move past the media hype and fear-mongering to look at the evidence-based truth written inside your cells. We are breaking down exactly how GLP-1 medications (Ozempic, Wegovy, Mounjaro, Zepbound) work, why they are so effective, and the specific biological costs from muscle loss to the "flatness" effect that patients need to understand.
In this video, we cover:
• The "Evolutionary Trap" that makes modern weight loss so difficult.
• The Gila Monster discovery that changed metabolic medicine.
• The difference between Semaglutide and Tirzepatide.
• The Invoice: The real risks regarding the stomach, anesthesia, and thyroid.
• The Protocol: How to come off these drugs safely without the "Rebound."
If you want clarity over confusion, please like this video and subscribe for more mechanism-first medical breakdowns.

0:00 The "Invoice" of Weight Loss
2:34 The Evolutionary Trap: Why You Can’t Lose Weight
4:04 The Lizard Brain: Ghrelin vs. Leptin
5:37 The Discovery
6:45 The Gila Monster Discovery
7:41 Engineering the 7-Day Hormone (Semaglutide)
8:54 Why Mounjaro Is Different (Tirzepatide)
10:10 The Trade-Offs: Stomach Issues & Gastroparesis
11:40 The Anesthesia Risk (Must Know)
12:36 Pancreas & Thyroid Warning Box
14:56 The Muscle Loss Crisis
16:27 "Ozempic Face" Explained
17:12 The "Flatness" Effect (Anhedonia)
18:34 The Rebound: Why Weight Comes Back
21:12 The Protocol: 5 Steps for Safe Use & Exit
26:28 A New Paradigm for Obesity

📚 REFERENCES & CITATIONS:
• Evolutionary Medicine Review (NEJM, 2020)
• Hunger & Willpower (Nature Reviews Endocrinology)
• The Incretin Effect (Journal of Clinical Investigation)
• Semaglutide Mechanisms (Nature Chemical Biology, 2017)
• Tirzepatide vs Semaglutide (NEJM, 2022)
• Gastric Emptying Risks (Clinical Gastroenterology and Hepatology, 2023)
• Muscle Loss & Rebound (Obesity Journal, 2023 / Endocrine Reviews, 2021)
• Dopamine & Reward Pathways (Translational Psychiatry, 2024)
Connect with Dr. Amin Hedayat:
Instagram/tiktok/youtube: @draminhedayat
Website: www.draminhedayat.com

MEDICAL DISCLAIMER
Educational Use Only: This video is for informational purposes only and does not constitute medical advice, diagnosis, or treatment.
No Doctor-Patient Relationship: Although Dr. Amin Hedayat is a board-certified physician, consuming this content does not establish a doctor-patient relationship.
Do Not Change Your Meds: This video discusses mechanisms and protocols, but you should never stop, taper, or alter your dosage of GLP-1 medications (e.g., Ozempic, Mounjaro) without direct supervision from your prescribing physician. Always consult your doctor before making changes to your health plan.
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